The 15th Winter Symposium on Chemometrics (WSC15) was held in Chimgan (Uzbekistan) from 23 to 27 February 2026. WSC-15 brought together 44 participants from eight countries. The conference program consisted of four keynote lectures, 21 oral presentation and 20 poster presentations. The variety of topics covered all modern aspects of chemometrics including signal processing, metabolomics, QSPR and numerous applications.